ABSTRACT
Objective To investigate the expression and clinical significance of PHH 3 and β-catenin in non-small cell lung cancer ( NSCLC) .Methods 78 cases of NSCLC tissue removed from June 2013 to June 2017 in Rizhao Central Hospital were collected .The expression of PHH3 and β-catenin protein in NSCLC and 30 cases of normal lung tissues were detected by immunohistochemical MaxVision method .The relationship between the expres-sion of PHH3 andβ-catenin protein was analyzed .The relationship between the expression of PHH 3,β-catenin and the clinicopathological features of NSCLC was analyzed .Results The positive rate of PHH3 in NSCLC tissues ( 57/78,73.1％) was significantly higher than that in normal lung tissues (2/30,6.7％)(χ2 =38.553,P<0.05).The expression level of PHH3 was significantly correlated with tumor differentiation (χ2 =5.248,P<0.05),lymph node metastasis(χ2 =7.747,P<0.05),but it was not related to the age (χ2 =0.209,P>0.05),gender(χ2 =0.033,P>0.05) and pathological type (χ2 =0.190,P>0.05).The positive rate of β-catenin in NSCLC tissues (54/78, 69.2％) was significantly higher than that in normal lung tissues (3/30,10.0％) (χ2 =30.499,P <0.05).The expression level of β-catenin was significantly correlated with tumor differentiation (χ2 =4.934,P<0.05),lymph node metastasis(χ2 =8.098,P<0.05),but it was not related to the age (χ2 =0.006,P>0.05),gender(χ2 =0.595,P>0.05) and pathological type (χ2 =0.071,P>0.05).The expression of PHH3 was positively correlated withβ-catenin(r=0.597,P<0.05).Kaplan-Meier analysis showed that PHH3 and β-catenin expression was negatively correlated with prognosis .Conclusion The overexpression of PHH3 and β-catenin in NSCLC may be related to the development ,invasion and metastasis of NSCLC ,which is expected to be an indicator of NSCLC ,and to predict invasion and metastasis .